Endocrine Abstracts

Summary: 59-year-old female diagnosed at the age of 41 in 2004 with pseudohypoparathyroidism (PHP) initially presenting with raised PTH 152 pmol/l (1.6-6.9), Phosphate 1.91 mmol/l (0.87-1.45), adjusted calcium 1.90 mmol/l (2.20-2.60), raised ALP 600 units/l (0-129) and low vitamin D 29 nmol/l. Since diagnosis started on alfacalcidol 1 mg daily and Calcichew-D3. Investigations by hepatology team in the view of persistently raised ALP showed normal liver ultrasound, Fibroscan an...

Case history: 48-years old man, with no comorbidities, presented to A&E due to global headache of 20 days duration, with associated intermittent vomiting, but no photophobia, cranial nerve impairment, neck pain or visual disturbance. The first head-scan (CT, computed tomography) was unremarkable, hence was discharged with safety advises. One week later, he represented to A&E with similar complaints. On enquiries, he mentioned to be reviewed by an optician 6 months ago,...

Introduction: Pituitary metastasis (PM) is a rare condition and associated with a reduced life-span. The most common primary sites are breast and lung, followed by thyroid and renal cell carcinoma. Patients with PM are mostly asymptomatic and incidentally discovered during neuroimaging. Characteristic symptoms are reported in <20% and most commonly include visual involvement, diabetes insipidus, and panhypopituitarism. We here describe a case with malignant melanoma (MM) w...

Introduction: Whether patients with non-surgical hypoparathyroidism have skeletal muscle dysfunction is not studied. It is also not known if skeletal muscle dysfunction involves respiratory muscles and results in a restrictive lung disease (RLD).Aim: To assess skeletal muscle and pulmonary function in patients with non-surgical hypoparathyroidism, who were asymptomatic for overt muscle and lung diseases.Methods: Thirty patients wit...

Introduction: Gestational trophoblastic disease (GTD) is a group of disorders arising from abnormal proliferation of placental trophoblasts. Hydatiform mole (molar pregnancy) is a premalignant condition which is further devided in to partial and complete mole. Incidence of molar pregnancy is estimated to be 1 in 1000 pregnancies. Hyperthyroidism is one of the rare complications of molar pregnancy which, if not detected and treated, can lead to adverse consequences. We describe...

Introduction: Adrenocortical Carcinoma (ACC) is a rare endocrine neoplasm with poor prognosis, and an estimated incidence of approximately 2.5/1,000,000 patients. The functional state of these tumors varies from non-secretory (20%) to non-secretory. The latter category is subdivided into glucocorticoid-producing (45%) or glucocorticoid-androgen producing (45%) or androgen-producing only (10%). We report a case of a 35-year-old lady who initially presented with symptoms of Cush...

Introduction: Cushing’s syndrome is a rare endocrine disorder characterized by excess cortisol secretion. It can be caused by various etiologies, including ACTH-dependent and ACTH-independent forms. We report a case of a 78-year-old male who presented with severe hypertension, refractory hypokalemia, and severe hypercortisolaemia, diagnosed with ACTH-dependent Cushing’s syndrome with bilateral adrenal hyperplasia.Case Presentation: A 78-year-ol...

Paradoxical severe hypercalcemia is a rare phenomenon observed in some patients in delayed phase following rhabdomyolysis. We present a case of 33-year-old male who developed severe hypercalcemia following successful treatment of rhabdomyolysis. Patient was admitted with agitation and disinhibition, was intubated in A&E due to metabolic acidosis (pH 6.7), hyperkalemia (K+ 7.3 mmol/l), lactic acidosis (23 mmol/l), and pyrexia (40°C). Toxicology screening shown presence...

Introduction: Hypocalcaemia is rare in patients with malignancy, occurring in <2% of patients with malignancy. Osteoblastic bone metastases as an aetiology of hypocalcaemia are further rare.Case description: A 75-year-old male presented to emergency with back pain, and immobility. He was diagnosed to have prostate cancer in 2019. A bone scan in April 2022 showed extensive sclerotic metastases involving axial and prox...